The aim of this review is to provide up-to-date clinical research evidence and to propose a concise clue-oriented diagnostic approach.ĭiagnostic imaging differential diagnosis fever granulomatous diseases imaging infection infections inflammation medical history taking neoplasms physical examination probiotics rheumatic diseases.

The clinicians task is to be able to identify these hallmark clinical features and to correctly interpret their significance and limitations in the appropriate differential diagnostic context. Each of the disease type is associated with rather characteristic symptoms, clinical signs and laboratory findings, which are individually non-specific, but may provide helpful clues for a further focused diagnostic work-up. These are classically divided into following categories: infections, non-infectious inflammatory diseases, malignancies, and other miscellaneous disorders. There have been described more than 200 potential diseases, that can manifest as a fever of unknown origin. There must be no obvious diagnosis despite complete history taking and examination. Fever of unknown origin is a rare clinical syndrome, that represents a significant diagnostic challenge. Fever of unknown origin (FUO) is body temperature 38.3 C ( 101 F) rectally that does not result from transient and self-limited illness, rapidly fatal illness, or disorders with clear-cut localizing symptoms or signs or with abnormalities on common tests such as chest x-ray, urinalysis, or blood cultures. Fever of unknown origin (FUO) is defined as a body temperature of 38.3☌ on at least two occasions and a duration of illness of 3 weeks or having multiple febrile episodes over this time period.